Selection of cross-over designs in restricted circumstances
27 mins 42 secs,
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| Description: |
Godolphin, J (Surrey)
Thursday 14 August 2008, 16:30-17:00 |
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| Created: | 2008-09-16 11:09 | ||
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| Collection: | Design and Analysis of Experiments | ||
| Publisher: | Isaac Newton Institute | ||
| Copyright: | Godolphin, J | ||
| Language: | eng (English) | ||
| Distribution: |
World
(downloadable)
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| Credits: |
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| Explicit content: | No | ||
| Aspect Ratio: | 4:3 | ||
| Screencast: | No | ||
| Bumper: | /sms-ingest/static/new-4x3-bumper.dv | ||
| Trailer: | /sms-ingest/static/new-4x3-trailer.dv | ||
| Abstract: | Cross-over designs are used extensively in clinical trials and many other fields. Restrictions in the availability of subjects may result in a set of parameters for which there is no known optimal design. This situation arises, for example, if the subjects comprise patients with a rare medical condition. A new class of cyclic cross-over designs is proposed. Designs in the class are shown to have lower average variances for direct and carry-over pairwise treatment contrasts than cross-over designs previously described in the literature. Consideration is also given to guarding against choosing a design that can become disconnected (and therefore unusable) if a few observations are lost during the period of experimentation. The techniques are illustrated by selection of a design for a clinical trial with specific numbers of treatments and subjects.
http://www.newton.ac.uk/programmes/DOE/seminars/index.html |
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