Spatial simulation and analysis of actin filament dynamics and wave propagation
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About this item
Description: |
Sanft, K (University of North Carolina)
Tuesday 21st June 2016 - 14:45 to 15:30 |
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Created: | 2016-07-04 14:34 |
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Collection: | Stochastic Dynamical Systems in Biology: Numerical Methods and Applications |
Publisher: | Isaac Newton Institute |
Copyright: | Sanft, K |
Language: | eng (English) |
Distribution: | World (downloadable) |
Explicit content: | No |
Aspect Ratio: | 16:9 |
Screencast: | No |
Bumper: | UCS Default |
Trailer: | UCS Default |
Abstract: | Co-authors: Hans Othmer (University of Minnesota), Yougan Cheng (University of Minnesota)
Actin filaments play an important role in many cellular processes, including cell motility. We present a stochastic model of actin filament dynamics in a three-dimensional Cartesian domain. Actin monomers bind to nucleation sites on the membrane and polymerize to form filaments (F-actin). F-actin polymers interact with membrane-bound nucleation promoting factors via a positive feedback loop. The resulting model produces waves of actin filaments that propagate along the membrane. Simulating polymer growth presents challenges to traditional Gillespie-type simulations. We describe a rule-based simulation approach to handle the many states of actin filament growth. Finally, we discuss techniques for managing the simulation output data. |
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