Spatial simulation and analysis of actin filament dynamics and wave propagation
Duration: 42 mins 38 secs
Share this media item:
Embed this media item:
Embed this media item:
About this item
| Description: |
Sanft, K (University of North Carolina)
Tuesday 21st June 2016 - 14:45 to 15:30 |
|---|
| Created: | 2016-07-04 14:34 |
|---|---|
| Collection: | Stochastic Dynamical Systems in Biology: Numerical Methods and Applications |
| Publisher: | Isaac Newton Institute |
| Copyright: | Sanft, K |
| Language: | eng (English) |
| Distribution: |
World
(downloadable)
|
| Explicit content: | No |
| Aspect Ratio: | 16:9 |
| Screencast: | No |
| Bumper: | UCS Default |
| Trailer: | UCS Default |
| Abstract: | Co-authors: Hans Othmer (University of Minnesota), Yougan Cheng (University of Minnesota)
Actin filaments play an important role in many cellular processes, including cell motility. We present a stochastic model of actin filament dynamics in a three-dimensional Cartesian domain. Actin monomers bind to nucleation sites on the membrane and polymerize to form filaments (F-actin). F-actin polymers interact with membrane-bound nucleation promoting factors via a positive feedback loop. The resulting model produces waves of actin filaments that propagate along the membrane. Simulating polymer growth presents challenges to traditional Gillespie-type simulations. We describe a rule-based simulation approach to handle the many states of actin filament growth. Finally, we discuss techniques for managing the simulation output data. |
|---|---|
Available Formats
| Format | Quality | Bitrate | Size | |||
|---|---|---|---|---|---|---|
| MPEG-4 Video | 640x360 | 1.94 Mbits/sec | 620.86 MB | View | Download | |
| WebM | 640x360 | 568.08 kbits/sec | 177.46 MB | View | Download | |
| iPod Video | 480x270 | 521.7 kbits/sec | 162.91 MB | View | Download | |
| MP3 | 44100 Hz | 249.82 kbits/sec | 78.07 MB | Listen | Download | |
| Auto * | (Allows browser to choose a format it supports) | |||||