An exact, efficient, and flexible representation of statistical models for DNA profiles

47 mins 48 secs,  182.84 MB,  iPod Video  480x270,  29.97 fps,  44100 Hz,  522.24 kbits/sec
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Description: Therese Graversen
Wednesday 9th November 2016 - 10:15 to 11:00
 
Created: 2016-11-11 16:17
Collection: Probability and Statistics in Forensic Science
Publisher: Isaac Newton Institute
Copyright: Therese Graversen
Language: eng (English)
Distribution: World     (downloadable)
Explicit content: No
Aspect Ratio: 16:9
Screencast: No
Bumper: UCS Default
Trailer: UCS Default
 
Abstract: Many different models have been proposed for a statistical interpretation of mixed DNA profiles. Regardless of the model, a computational bottleneck lies in the necessity to handle the large set of possible combinations of DNA profiles for the contributors to the DNA sample.

I will explain how models can be specified in a very general setup that makes it simple to compute both the likelihood and many other quantities that are crucial to a thorough statistical analysis. Notably all computations in this setup are exact, whilst still efficient.

I have used this setup to implement the statistical software package DNAmixtures.

Related Links

http://dnamixtures.r-forge.r-project.org/ - The DNAmixtures software package
http://dx.doi.org/10.1007/s11222-014-9451-7 - Computational aspects of DNA mixture analysis (Graversen and Lauritzen 2015)
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