Fundamental limits to transcriptional regulatory control
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About this item
| Description: |
ten Wolde, P R
Thursday 7th April 2016 - 09:00 to 09:45 |
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| Created: | 2016-04-12 10:29 |
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| Collection: | Stochastic Dynamical Systems in Biology: Numerical Methods and Applications |
| Publisher: | Isaac Newton Institute |
| Copyright: | ten Wolde, P R |
| Language: | eng (English) |
| Distribution: |
World
(downloadable)
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| Explicit content: | No |
| Aspect Ratio: | 16:9 |
| Screencast: | No |
| Bumper: | UCS Default |
| Trailer: | UCS Default |
| Abstract: | Gene expression is typically regulated by gene regulatory proteins that bind to the DNA. Experiments have shown that these proteins find their DNA target site via a combination of 3D diffusion in the cytoplasm and 1D diffusion along the DNA. This stochastic transport sets a fundamental limit on the precision of gene regulation. We derive this limit analytically and show by particle-based GFRD simulations that our expression is highly accurate under biologically relevant conditions. |
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