First-passage time to clear the way for receptor-ligand binding in a crowded environment
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| Description: |
Newby, J
Tuesday 5th April 2016 - 11:45 to 12:30 |
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| Created: | 2016-04-06 10:26 |
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| Collection: | Stochastic Dynamical Systems in Biology: Numerical Methods and Applications |
| Publisher: | Isaac Newton Institute |
| Copyright: | Newby, J |
| Language: | eng (English) |
| Distribution: |
World
(downloadable)
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| Explicit content: | No |
| Aspect Ratio: | 16:9 |
| Screencast: | No |
| Bumper: | UCS Default |
| Trailer: | UCS Default |
| Abstract: | I will present theoretical support for a hypothesis about cell-cell contact, which plays a critical role in immune function. A fundamental question for all cell-cell interfaces is how receptors and ligands come into contact, despite being separated by large molecules, the extracellular fluid, and other structures in the glycocalyx. The cell membrane is a crowded domain filled with large glycoproteins that impair interactions between smaller pairs of molecules, such as the T cell receptor and its ligand, which is a key step in immunological information processing and decision-making. A first passage time problem allows us to gauge whether a reaction zone can be cleared of large molecules through passive diffusion on biologically relevant timescales. I combine numerical and asymptotic approaches to obtain a complete picture of the first passage time, which shows that passive diffusion alone would take far too long to account for experimentally observed cell-cell contact format ion times. The result suggests that cell-cell contact formation may involve previously unknown active mechanical processes. |
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