Chemo-mechanical modeling of morphogenesis in living matter
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| Description: |
Ciarletta, P (Politecnico di Milano)
Thursday 10th December 2015 - 14:15 to 15:00 |
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| Created: | 2015-12-21 11:18 |
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| Collection: | Coupling Geometric PDEs with Physics for Cell Morphology, Motility and Pattern Formation |
| Publisher: | Isaac Newton Institute |
| Copyright: | Ciarletta, P |
| Language: | eng (English) |
| Distribution: |
World
(downloadable)
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| Explicit content: | No |
| Aspect Ratio: | 16:9 |
| Screencast: | No |
| Bumper: | UCS Default |
| Trailer: | UCS Default |
| Abstract: | Life phenomena result from the mutual equilibrium between the living matter and the surrounding media. A network of servo-mechanisms physiologically restores the stable equilibrium between the interior matter of a living entity in the face of external perturbative agents. In particular, living cells can balance exogenous and endogenous forces using an iterative process, also known as mechano-reciprocity. Hence, not only living matter can adapt through epigenetic remodelling to the external physical cues, but it can also respond by activating gene regulatory processes, which may also drive the onset of pathologies, e.g. solid tumours. Moreover, living materials have the striking ability to change actively their micro-structural organization in order to adjust their functions to the surrounding media, developing a state of internal tension, which even persists after the removal of any external loading. This complex mechanical and biochemical interaction can finally control morp hogenesis during growth and remodelling, leading to shape instabilities characterized by a complex morphological phase diagram. In this lecture, I will introduce few mathematical s of mechanobiology and morphogenesis in living materials [1,2], with several applications concerning solid tumours [3], gastro-intestinal organogenesis [4], bacterial colonies [5] and nerve fibers [6]. [1] Ciarletta P, Ambrosi D, Maugin G A, Preziosi L. THE EUROPEAN PHYSICAL JOURNAL. E, SOFT MATTER, 2013, 36, 23-28. [2] Ciarletta P, Preziosi L, Maugin GA. JOURNAL OF THE MECHANICS AND PHYSICS OF SOLIDS, 2013, 61, 852-872; [3] Ciarletta P. Buckling instability in growing tumour spheroids. PHYSICAL REVIEW LETTERS, 2013, 110. [4] Ciarletta P., Balbi V., Kuhl, E. Pattern selection in growing tubular tissues. PHYSICAL REVIEW LETTERS, 2014, 113, 248101. [5] Giverso, C., Verani M., Ciarletta P. JOURNAL OF THE ROYAL SOCIETY INTERFACE, 2015, 12 [6] Taffetani M., Ciarletta P, PHYSICAL REVIEW E, 2015,91 |
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