Self-organization of adipose tissue
52 mins 8 secs,
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| Description: |
Degond, P (Imperial College London)
Wednesday 16th September 2015 - 14:15 to 15:00 |
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| Created: | 2015-09-29 14:58 |
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| Collection: | Coupling Geometric PDEs with Physics for Cell Morphology, Motility and Pattern Formation |
| Publisher: | Isaac Newton Institute |
| Copyright: | Degond, P |
| Language: | eng (English) |
| Distribution: |
World
(downloadable)
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| Explicit content: | No |
| Aspect Ratio: | 16:9 |
| Screencast: | No |
| Bumper: | UCS Default |
| Trailer: | UCS Default |
| Abstract: | One of the key functions of adipose tissue is to store energy for the needs of the organism. Dysfunction of adipose tissue results in conditions like obesity which affect an increasing number of people worldwide. In 2007, it was estimated that 50% of women and 65% of men in UK were overweight or obese. Yet, very few studies of how adipose tissue organizes during its development are available. The fat storing cells or adipocytes are organized in lobular structures separated by collagen fiber septa. In this work, we use an individual-based model to investigate scenarios for the formation of these lobules. We find that they could result from the combination of volume exclusion constraints between the adipocytes and confinement by the elasticity of the collagen fibers. In particular, the model shows that vasculature does not seem to notably influence the outcome of this morphogenesis process. This study suggests that the role of vaculature in adipogenesis could be more complex than originally thought. |
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