Cell Motility and Signalling to the Cytoskeleton
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About this item
| Description: |
Ridley, A (King's College London)
Thursday 16th July 2015, 15:15 to 16:30 |
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| Created: | 2015-07-17 18:35 |
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| Collection: | Coupling Geometric PDEs with Physics for Cell Morphology, Motility and Pattern Formation |
| Publisher: | Isaac Newton Institute |
| Copyright: | Ridley, A |
| Language: | eng (English) |
| Distribution: |
World
(downloadable)
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| Explicit content: | No |
| Aspect Ratio: | 16:9 |
| Screencast: | No |
| Bumper: | UCS Default |
| Trailer: | UCS Default |
| Abstract: | Cells move in response to extracellular cues in their environment. Cell motility is driven by the cytoskeleton, principally actin filaments and microtubules. Rho family GTPases are intracellular signal transducers that coordinate cell motility through their effects on the cytoskeleton and cell adhesions. Most of the 20 human Rho GTPases cycle between a GTP-bound active form and a GDP-bound inactive form, although RhoH and Rnd proteins are constitutively GTP-bound. Rho GTPases are activated in response to a wide variety of extracellular cues. Rho GTPases are regulated by and activate a complex network of proteins, including protein kinases, which lead to changes in cytoskeletal dynamics and cell contractility. I will describe results of RNAi screens we have carried out of Rho GTPase network components, including new links between Rho family members and protein kinases. |
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