Multiscale Modelling of Cell-ECM interaction
1 hour 11 mins,
131.30 MB,
MP3
44100 Hz,
252.49 kbits/sec
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| Description: |
Preziosi, L (Politecnico di Torino)
Thursday 16th July 2015, 09:00 to 10:15 |
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| Created: | 2015-07-17 18:34 |
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| Collection: | Coupling Geometric PDEs with Physics for Cell Morphology, Motility and Pattern Formation |
| Publisher: | Isaac Newton Institute |
| Copyright: | Preziosi, L |
| Language: | eng (English) |
| Distribution: |
World
(downloadable)
|
| Explicit content: | No |
| Aspect Ratio: | 16:9 |
| Screencast: | No |
| Bumper: | UCS Default |
| Trailer: | UCS Default |
| Abstract: | Cell-extracellular matrix interaction and the mechanical properties of cell nucleus have been demonstrated to play a fundamental role in cell movement across fibre networks and micro-channels. In the talk, we will describe several mathematical models dealing with such a problem, starting from modelling cell adhesion mechanics to the inclusion of influence of nucleus stiffness in the motion of cells. An energetic approach is used in order to obtain a necessary condition for which cells enter cylindrical structures. The nucleus of the cell is treated either (i) as an elastic membrane surrounding a liquid droplet or (ii) as an incompressible elastic material with Neo-Hookean constitutive equation. The results obtained highlight the importance of the interplay between mechanical deformability of the nucleus and the capability of the cell to establish adhesive bonds. |
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