# Cardiac Physiome Project

Created: | 2009-07-22 15:47 |
---|---|

Institution: | Isaac Newton Institute for Mathematical Sciences |

Editors' group: | SMS Editors group for the Newton Institute |

Description: | Predicting physiological behaviour from experimental data combined with environmental influences is a compelling, but unfulfilled, goal of post-genomic biology. This undeniably ambitious goal is the aim of the Physiome Project and its subset the Cardiome Project which is an international effort to build a biophysically based multi-scale mathematical model of the heart. To achieve this goal requires further development of the current generation of advanced cardiac models which span an already diverse set of mathematical representations from stochastic sub-cellular regulation models to whole-organ-based sets of coupled partial differential equations. The focus of this programme will be on the development and application of the mathematical techniques which underpin the ongoing extension of this approach, and specifically to:
* integrate data from disparate sources into a common quantitative framework; * examine the complex cause and effect relationships which exist across many temporal and spatial orders of magnitude in physiology; * determine the appropriate level of detail to capture observable phenomena and the closely related issue of parameter identifiability; * examine issues of model inheritance and multi-scale coupling for combining existing models together to create extended frameworks; * define standards for the constituent electrical, mechanical and vascular classes of cardiac models. Read more at: www.newton.ac.uk/programmes/CPP/ |

# Media items

This collection contains 56 media items.

### Media items

#### 3D/1D geometrical multiscale modeling of vascular networks

810 views

Passerini, T (Emory)

Tuesday 21 July 2009, 10:45-11:00

**Collection**:
Cardiac Physiome Project

**Institution**:
Isaac Newton Institute for Mathematical Sciences

**Created**:
Wed 22 Jul 2009

#### A novel approach to multidomain modeling of electrical conduction in cardiac tissue

793 views

Sachse, F (Utah)

Monday 20 July 2009, 16:15-16:30

**Collection**:
Cardiac Physiome Project

**Institution**:
Isaac Newton Institute for Mathematical Sciences

**Created**:
Wed 22 Jul 2009

#### A posteriori error estimation and adaptivity for operator decomposition methods

413 views

Tavener, S (Colorado State)

Tuesday 21 July 2009, 14:15-14:30

**Collection**:
Cardiac Physiome Project

**Institution**:
Isaac Newton Institute for Mathematical Sciences

**Created**:
Thu 23 Jul 2009

#### Adaptive Tetrahedral Meshing for Personalized Cardiac Simulations

672 views

Delingette, H (INRIA)

Thursday 23 July 2009, 14:45-15:00

**Collection**:
Cardiac Physiome Project

**Institution**:
Isaac Newton Institute for Mathematical Sciences

**Created**:
Mon 27 Jul 2009

#### An attempt for dialectics: what can we learn from interdigitating wet and dry research into structure and function...

364 views

Kohl, P (Oxford)

Tuesday 21 July 2009, 14:45-15:00

**Collection**:
Cardiac Physiome Project

**Institution**:
Isaac Newton Institute for Mathematical Sciences

**Created**:
Thu 23 Jul 2009

#### Building detailed cardiac electrophysiological models from high-resolution images

610 views

Grau, V (Oxford)

Wednesday 22 July 2009, 10:45-11:00

**Collection**:
Cardiac Physiome Project

**Institution**:
Isaac Newton Institute for Mathematical Sciences

**Created**:
Fri 24 Jul 2009

#### Building tissue mechanics into novel types of multi-scale models

696 views

Jensen, O (Nottingham)

Friday 24 July 2009, 10:15-10:30

**Collection**:
Cardiac Physiome Project

**Institution**:
Isaac Newton Institute for Mathematical Sciences

**Created**:
Wed 29 Jul 2009

#### CellML language and tools supporting the cardiac physiome

495 views

Nielsen, P (Auckland)

Friday 24 July 2009, 10:45-11:00

**Collection**:
Cardiac Physiome Project

**Institution**:
Isaac Newton Institute for Mathematical Sciences

**Created**:
Wed 29 Jul 2009

#### Clinically observed phenomena on cardiac energetics in heart failure emerge from simulations of cardiac metabolism

627 views

Beard, D (Medical College of Wisconsin)

Monday 20 July 2009, 12:15-12:30

**Collection**:
Cardiac Physiome Project

**Institution**:
Isaac Newton Institute for Mathematical Sciences

**Created**:
Wed 22 Jul 2009

#### Closing comments

596 views

Smith, N (Oxford)

Friday 24 July 2009, 11:45-12:00

**Collection**:
Cardiac Physiome Project

**Institution**:
Isaac Newton Institute for Mathematical Sciences

**Created**:
Wed 29 Jul 2009

#### Commented Poster Session 1

411 views

Commented Posters at the The Cardiac Physiome: Multi-scale and Multi-physics Mathematical Modelling Applied to the Heart conference.

**Collection**:
Cardiac Physiome Project

**Institution**:
Isaac Newton Institute for Mathematical Sciences

**Created**:
Wed 22 Jul 2009

#### Commented Poster Session 2

409 views

Commented Posters at the The Cardiac Physiome: Multi-scale and Multi-physics Mathematical Modelling Applied to the Heart conference.

**Collection**:
Cardiac Physiome Project

**Institution**:
Isaac Newton Institute for Mathematical Sciences

**Created**:
Fri 24 Jul 2009

#### Computational modelling to investigate the role of aging and species on arterial branch lesion patterns

1,119 views

Sherwin, S (Imperial College London)

Wednesday 22 July 2009, 13:45-14:00

**Collection**:
Cardiac Physiome Project

**Institution**:
Isaac Newton Institute for Mathematical Sciences

**Created**:
Thu 21 Jan 2010

#### Connexins, buffers and mitochondria: novel pH/Ca2+ regulators in heart

713 views

Vaughan-Jones, R (Oxford)

Monday 20 July 2009, 10:00-10:45

**Collection**:
Cardiac Physiome Project

**Institution**:
Isaac Newton Institute for Mathematical Sciences

**Created**:
Wed 22 Jul 2009

#### Development and testing of Cardiac Physiome cell model parts in skeletal muscle

422 views

Jeneson, J (TU, Eindhoven)

Monday 20 July 2009, 12:00-12:15

**Collection**:
Cardiac Physiome Project

**Institution**:
Isaac Newton Institute for Mathematical Sciences

**Created**:
Wed 22 Jul 2009

#### Development of a virtual heart - Part l

891 views

Boyett, M (Manchester)

Monday 20 July 2009, 14:30-14:45

**Collection**:
Cardiac Physiome Project

**Institution**:
Isaac Newton Institute for Mathematical Sciences

**Created**:
Wed 22 Jul 2009

#### Development of a virtual heart - Part ll

703 views

Zhang, H (Manchester)

Monday 20 July 2009, 14:45-15:00

**Collection**:
Cardiac Physiome Project

**Institution**:
Isaac Newton Institute for Mathematical Sciences

**Created**:
Wed 22 Jul 2009

#### Dynamic modelling of chorded mitral valve

556 views

Luo, X (Glasgow)

Wednesday 22 July 2009, 14:30-14:45

**Collection**:
Cardiac Physiome Project

**Institution**:
Isaac Newton Institute for Mathematical Sciences

**Created**:
Fri 24 Jul 2009

#### Electrophysiological metric and geometry of the heart

891 views

Panfilov, S (Utrecht)

Monday 20 July 2009, 15:30-15:45

**Collection**:
Cardiac Physiome Project

**Institution**:
Isaac Newton Institute for Mathematical Sciences

**Created**:
Wed 22 Jul 2009

#### Fluid solid interaction for vascular applications

750 views

Hose, R (Sheffield)

Wednesday 22 July 2009, 13:30-13:45

**Collection**:
Cardiac Physiome Project

**Institution**:
Isaac Newton Institute for Mathematical Sciences

**Created**:
Fri 24 Jul 2009